反应详情

Methyl 2-[2-(4-{2-[(2,4-difluorobenzyl)(propyl)amino]-2-oxoethoxy}phenyl)-ethoxy]benzoate (0.22 g, 0.442 mmol) was dissolved in a mixture of THF/water (1/1, 4 ml). Lithium hydroxide (0.021 g, 0.884 nmol) was added. The reaction was performed in an single node microwave oven (14 min, 150 deg). Work-up by removing the solvent by evaporation and addition of HCl (2 ml, 1 M). The waterphase was extracted with two portions of EtOAc (20 ml), the organic phase was dried (MgSO4) and the solvent was removed by evaporation to give 0.180 g of 2-[2-(4-{2-[(2,4-difluorobenzyl)(propyl)-amino]-2-oxoethoxy}phenyl)ethoxy]benzoic acid (yield 84.2%).

1. customThe reaction was performed in an single node microwave oven
2. custom(14 min, 150 deg)
3. customby removing the solvent
4. customby evaporation and addition of HCl (2 ml, 1 M)
5. extractionThe waterphase was extracted with two portions of EtOAc (20 ml)
6. dry with materialthe organic phase was dried (MgSO4)
7. customthe solvent was removed by evaporation