反应详情

Methyl 2-{[2-(4-{2-[benzyl(ethyl)amino]-2-oxoethoxy}phenyl)ethyl]thio}benzoate (0.137 g, 0.296 mmol) was dissolved in a mixture of acetonitrile/water (1/1, 4 ml), lithium hydroxide (0.014 g, 0.591 mmol) was added. The reaction was performed in an single node microwave oven (5 min, 150 deg). Work-up by removing the solvent by evaporation and addition of HCl (2 ml, 1 M). The waterphase was extracted with two portions of EtOAc (20 ml), the organic phase was dried (MgSO4) and the solvent was removed by evaporation and gave 0.111 g of 2-{[2-(4-{2[-benzyl(ethyl)amino]-2-oxoethoxy}phenyl)ethyl]-thio}benzoic acid (yield 83.5%).

1. additionwas added
2. customThe reaction was performed in an single node microwave oven
3. custom(5 min, 150 deg)
4. customby removing the solvent
5. customby evaporation and addition of HCl (2 ml, 1 M)
6. extractionThe waterphase was extracted with two portions of EtOAc (20 ml)
7. dry with materialthe organic phase was dried (MgSO4)
8. customthe solvent was removed by evaporation