5-(phenylmethoxy)-1H-indole-2-carboxylic acid → 5-Benzyloxy-3-(dimethylaminophenylmethyl)-1H-indole-2-carboxylic Acid

HRID 8991Notes

Reaction equation

HRID 8991 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([C:18]([OH:20])=[O:19])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH:22](=[N+:29]([CH3:31])[CH3:30])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([C:18]([OH:20])=[O:19])=[C:12]2[CH:22]([N:29]([CH3:31])[CH3:30])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 811465-(phenylmethoxy)-1H-indole-2-carboxylic acidHCID 11073839Methanaminium, N-methyl-N-(phenylmethylene)-, chloride

Product 1

HCID 101356205-Benzyloxy-3-(dimethylaminophenylmethyl)-1H-indole-2-carboxylic Acid

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 5-benzyloxy-1H-indole-2-carboxylic acid and benzylidene-dimethyl-ammonium chloride, which had been prepared in accordance with example 1.

Workup

  1. customhad been prepared in accordance with example 1

Sources & evidence

ORD record
ord-a26ba1aa91024edd8cc9a52003c2eac1
Source dataset
uspto-grants-2006_08
Patent number
US07091220B2

Reaction notes

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