反应详情

To a solution of methanesulfonic acid 2-{[2-(4-cyanophenoxy)ethyl]-methanesulfonylamino}ethyl ester (10 g, 0.028 mol; see step (iii) above) in dry acetone (100 mL), was added lithium bromide (4.8 g, 0.055 mol). The reaction mixture was added refluxed overnight under a nitrogen atmosphere, before being filtered and concentrated to give the title compound. Yield: 10 g (97%).

1. additionThe reaction mixture was added
2. temperaturerefluxed overnight under a nitrogen atmosphere
3. filtrationbefore being filtered
4. concentrationconcentrated