Urea → 1-[3-(4-Cyanophenyl)propyl]-1-(2-hydroxyethyl)urea
Reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1.[NH2:16][C:17](N)=[O:18]>O>[C:12]([C:11]1[CH:14]=[CH:15][C:8]([CH2:7][CH2:6][CH2:5][N:4]([CH2:3][CH2:2][OH:1])[C:17]([NH2:16])=[O:18])=[CH:9][CH:10]=1)#[N:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
4-[3-(2-Hydroxyethylamino)propyl]benzonitrile (6.7 g, 0.0328 mol; see Preparation A(v) above) and urea (2 g, 0.0328 mol) were mixed and heated at 130° C. for 2 h. The reaction mixture was cooled to room temperature and water was added. The resulting solid was filtered and dried to give 5.9 g (72%) of the sub-title compound as a white solid.
Workup
- temperatureThe reaction mixture was cooled to room temperature
- filtrationThe resulting solid was filtered
- customdried
Sources & evidence
- ORD record
- ord-fe88e7508e4949ee8e24b57e4589944e
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07354917B2
Reaction notes
Loading…