Benzylethanolamine → HCID 69070027, compound

HRID 899144Notes

Reaction equation

HRID 899144 reaction equation
[CH2:1]([NH:8][CH2:9][CH2:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][NH:13][C:14](NC)=[O:15]>>[CH2:1]([N:8]([CH2:9][CH2:10][OH:11])[C:14]([NH:13][CH3:12])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4348BenzylethanolamineHCID 7293N,N'-Dimethylurea

Product 1

HCID 69070027HCID 69070027, compound

Conditions

Temperature
130 °C

Procedure

A mixture of N-benzyl ethanolamine (3 g, 0.0198 mol) and N,N′-dimethyl urea was stirred at 130° C. overnight. The reaction mixture was cooled to RT and the crude product was purified by column chromatography over silica gel using 3% methanol in dichloromethane as eluent to yield 3.5 g of the sub-title compound as a liquid.

Workup

  1. temperatureThe reaction mixture was cooled to RT
  2. customthe crude product was purified by column chromatography over silica gel using 3% methanol in dichloromethane as eluent

Sources & evidence

ORD record
ord-47be5271e39f41f0b1af2557fb0d6744
Source dataset
uspto-grants-2008_04
Patent number
US07354917B2

Reaction notes

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