Water → N-Benzyl-4'-nitrobiphenyl-4-sulfonamide

HRID 899175Notes

Reaction equation

HRID 899175 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)([O-:11])=[O:10].O>CN(C=O)C>[CH2:1]([NH:8][S:24]([C:21]1[CH:22]=[CH:23][C:18]([C:15]2[CH:16]=[CH:17][C:12]([N+:9]([O-:11])=[O:10])=[CH:13][CH:14]=2)=[CH:19][CH:20]=1)(=[O:25])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7504BenzylamineHCID 27601854'-Nitrobiphenyl-4-sulfonyl chloride

Product 1

HCID 59694084N-Benzyl-4'-nitrobiphenyl-4-sulfonamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.28 ml (2.52 mmol) of benzylamine is added to a solution of 150 mg (0.50 mmol) of 4′-nitrobiphenyl-4-sulfonyl chloride in 2.0 ml of DMF. After 18 h at room temperature, 2.5 ml of water are added to the reaction mixture. The resulting precipitate is filtered off with suction and dried under high vacuum. 159 mg (74.4% of theory) of the title compound are obtained and reacted further without further purification.

Workup

  1. filtrationThe resulting precipitate is filtered off with suction
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-b5092daadb1842dab0645e7292636d3b
Source dataset
uspto-grants-2008_04
Patent number
US07354930B2

Reaction notes

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