反应详情

Propynyllithium (21 mg) was added to a solution of Example 52 (41 mg) in tetrahydrofuran (5 ml) at −78° C. The reaction was quenched with methanol at −25° C. in 2 hours. After solvents were removed under vaccum, the residue was carried to the further reactions without any purification. I-64, 1-benzoyl-3-(R)-methyl-4-[(7-(2-propynyl)carbonyl-4-azaindol-3-yl)-oxoacetyl]piperazine MS m/z: (M+H)+ Calc'd for C25H22ClN4O4: 477.13; found 477.17. HPLC retention time: 1.46 minutes (column A).

1. customThe reaction was quenched with methanol at −25° C. in 2 hours
2. customAfter solvents were removed under vaccum
3. customthe residue was carried to the further reactions without any purification