反应详情

温度

10 °C

5-Methoxy-benzo-[2,1,3]-thiadiazole (4.09 g, 24.6 mmol) was stirred with hydrobromic acid (60 ml, 165 mmol, 30% in acetic acid) at 80° C. for 5 days. The mixture was cooled to 10° C. and filtered. The solids were purified by short column chromatography (50% ethyl acetate/hexane). Solvents were stripped in vacuo to afford 1.0 g of a yellow solid (27% yield).

1. filtrationfiltered
2. customThe solids were purified by short column chromatography (50% ethyl acetate/hexane)