Acetic Anhydride → HCID 10081676, compound

HRID 899607Notes

Reaction equation

HRID 899607 reaction equation
[N+:1]1([O-])[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:2]=12.[C:13]([O:16]C(=O)C)(=[O:15])[CH3:14]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([O:16][C:13](=[O:15])[CH3:14])[C:2]=12

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 5896891-Oxo-6,7,8,9-tetrahydro-5H-1lambda~5~-cyclohepta[b]pyridine

Product 1

HCID 10081676HCID 10081676, compound

Conditions

Temperature
90 °C

Procedure

The N-oxide was dissolved in acetic anhydride (222 mL) and heated at 90° C. overnight. The mixture was cooled to room temperature and concentrated. Distillation (Kugelrohr, bp 110-140° C.@1 Torr) of the resultant oil provided 53.26 g of acetic acid 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. concentrationconcentrated
  3. distillationDistillation (Kugelrohr, bp 110-140° C.@1 Torr) of the resultant oil

Sources & evidence

ORD record
ord-2f267a8c76b545b8bf7fee25cb9767d6
Source dataset
uspto-grants-2008_04
Patent number
US07354932B2

Reaction notes

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