反应详情

Methyl 2-{[(4-{3-[(2,4-difluorobenzyl)(heptyl)amino]-3-oxopropyl}phenyl)thio]methyl}benzoate (1.05 g, 1.89 mmol) was dissolved in EtOH (95%, 5 ml), potassium hydroxide (0.21 g, 3.77 mmol) was added. The reaction was performed in a single node microwave oven (7 min, 150° C.). Workup was by addition of EtOAc (5 ml) and washing with HCl (2×5 ml, 1M). The organic layer was dried (MgSO4) and the solvent was removed by evaporation to give 0.96 gram of 2-{[(4-{3-[(2,4-difluorobenzyl)(heptyl)amino]-3-oxopropyl}phenyl)thio]methyl}benzoic acid (yield 94.3%).

1. customThe reaction was performed in a single node microwave oven
2. custom(7 min, 150° C.)
3. washwashing with HCl (2×5 ml, 1M)
4. dry with materialThe organic layer was dried (MgSO4)
5. customthe solvent was removed by evaporation