Water → HCID 22179844, compound

HRID 900075Notes

Reaction equation

HRID 900075 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30].O>ClCCl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[CH:11][CH:12]=2)[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 22179838HCID 22179838, compound

Product 1

HCID 22179844HCID 22179844, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 5B (671 mg, 1.725 mmol) in dichloromethane (2 mL) at room temperature was treated with TFA (1.8 mL) and water (0.2 mL) allowed to stand for 2 hours The solution was concentrated to provide the desired product.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-38731cd2c6b342ca949009b0558c14a5
Source dataset
uspto-grants-2008_04
Patent number
US07358251B2

Reaction notes

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