反应详情

A solution of 5 g 5-Methyl-3H-imidazole-4-carboxylic acid ethyl ester and 7.2 g NIS in 50 ml THF were refluxed for 10 h. After cooling, the solvent was removed under reduced pressure and the residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution and dried over MgSO4. After removal of the solvent under reduced pressure the product was purified by recrystallisation from ethyl acetate. Yield: 7 g

1. temperatureAfter cooling
2. customthe solvent was removed under reduced pressure
3. washthe residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution
4. dry with materialdried over MgSO4
5. customAfter removal of the solvent under reduced pressure the product
6. customwas purified by recrystallisation from ethyl acetate