反应详情

温度

110 °C

To a solution of 1 g 2-Iodo-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester in 3 ml pyridine 640 mg CuCN were added and the mixture stirred for 3 h at 110° C. Then the pyridine was removed under reduced pressure and the residue was directly purified by chromatography on silica eluting with DCM/MeOH 97:3. Yield: 494 mg.

1. customThen the pyridine was removed under reduced pressure
2. customthe residue was directly purified by chromatography on silica eluting with DCM/MeOH 97:3