HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900238Generated: October 31, 2026
Pyridine → 2-Cyano-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester
https://huagongshe.com/reaction/900238
Participants
| Role | Name | HCID | Charge |
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| Reactant | Pyridine | HCID 1049 | — |
| Reactant | HCID 178470396 | HCID 178470396 | — |
| Product | 2-Cyano-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester | HCID 178470394 | — |
Reaction Steps
To a solution of 1 g 2-Iodo-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester in 3 ml pyridine 640 mg CuCN were added and the mixture stirred for 3 h at 110° C. Then the pyridine was removed under reduced pressure and the residue was directly purified by chromatography on silica eluting with DCM/MeOH 97:3. Yield: 494 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07358268B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-9a2880d9c85343aa94cb5cd7092eb253 |
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| Source note | uspto-grants-2008_04 |
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