反应详情

500 mg (2.0 mmol) of 2-(4-Chlorophenyl)-3H-imidazole-4-carboxylic acid ethyl ester was dissolved in 5 ml of DMF and 2.6 g (8 mmol) of cesium carbonate were added at RT. After stirring for 15 min, 445 mg (1.6 mmol) of 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole were added. The reaction was stirred at room temperature for 16 h. The reaction solution was filtered and the product was purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid). After lyophilization the product was obtained as a white solid. Yield: 480 mg; MS (LCMS-ES+): m/e=448.

1. stirringThe reaction was stirred at room temperature for 16 h
2. filtrationThe reaction solution was filtered
3. customthe product was purified by preparative RP-HPLC
4. washeluting with a gradient of 0-100% acetonitrile in water (+0.01% trifluoroacetic acid)
5. customAfter lyophilization the product was obtained as a white solid