反应详情

温度

0 °C

To a solution of 3-{1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-imidazol-4-yl}-propionic acid methyl ester (140 mg) and NEt3 (70 μL) in DCM (5 mL) was added a solution of trichloroacetyl chloride (50 μL) in DCM (1 mL) dropwise at 0° C. The mixture was stirred for 5 min at 0° C. and for 30 min at RT. More NEt3 (280 μL) and 1-isopropyl-piperidin-4-ylamine dihydrochloride (88 mg) were added and stirring was continued for 2 h at RT. The mixture was concentrated and the residue was purified by preparative HPLC. The fractions containing the product were evaporated to provide 47 mg of the title compound as its trifluoroacetate salt. MS (ESI+): m/e=520, chloro pattern.

1. stirringstirring
2. waitwas continued for 2 h at RT
3. concentrationThe mixture was concentrated
4. customthe residue was purified by preparative HPLC
5. additionThe fractions containing the product
6. customwere evaporated