反应详情

To a solution of 1-(3-methoxy-benzyl)-1H-imidazole (100 mg) and NEt3 (147 μL) in DCM (5 mL) was added trichloroacetyl chloride (106 μL) dropwise. The mixture was stirred for 2 h at RT. More NEt3 (147 μL) and 1-isopropyl-piperidin-4-ylamine (76 mg) were added and stirring was continued for 1 h at RT. The mixture was quenched by the addition of MeOH, concentrated and the residue was purified by preparative HPLC. The fractions containing the product were evaporated to provide 30 mg of the title compound as its trifluoroacetate salt. MS (ESI+): m/e=357.

1. stirringstirring
2. waitwas continued for 1 h at RT
3. customThe mixture was quenched by the addition of MeOH
4. concentrationconcentrated
5. customthe residue was purified by preparative HPLC
6. additionThe fractions containing the product
7. customwere evaporated