HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900253Generated: October 30, 2026
Imidazole → 5-(5-Chloro-thiophen-2-yl)-3-imidazol-1-ylmethyl-isoxazole
https://huagongshe.com/reaction/900253
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole | HCID 11150146 | — |
| Catalyst | Hexadecyl(trimethyl)phosphanium bromide | HCID 23496269 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(5-Chloro-thiophen-2-yl)-3-imidazol-1-ylmethyl-isoxazole | HCID 69112068 | 115.4% |
Reaction Steps
To a solution of imidazole (34 mg) in MeCN (3 mL) was added K2CO3 (138 mg), n-hexadecyltrimethylphosphonium bromide (1 mg) and 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole (139 mg). The mixture was stirred for 3 h at 70° C. After cooling to RT the reaction mixture was diluted with DCM (5 mL) and filtered. The filtrate was concentrated in vacuo to give crude 5-(5-Chloro-thiophen-2-yl)-3-imidazol-1-ylmethyl-isoxazole (153 mg) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07358268B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-0242ba618bbd4ad4ba692f10e9dae8bc |
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| Source note | uspto-grants-2008_04 |
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