Pivaloyl chloride → HCID 22182242, compound

HRID 900402Notes

Reaction equation

HRID 900402 reaction equation
[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([O:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:4][C:3]1([CH3:20])[CH3:19].[C:21](Cl)(=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23]>>[C:11]([O:10][CH:5]1[CH2:6][C:7]([CH3:9])([CH3:8])[N:2]([O:1][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23])[C:3]([CH3:20])([CH3:19])[CH2:4]1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 62493Pivaloyl chlorideHCID 6881781-Hydroxy-4-benzoyloxy-2,2,6,6-tetramethylpiperidine

Product 1

HCID 22182242HCID 22182242, compoundYield 70%

Procedure

Using 1-hydroxy-4-benzoyloxy-2,2,6,6-tetramethylpiperidine (prepared as described by: Kurumada T. et. al., loc. cit.) and pivaloyl chloride in a procedure otherwise similar to the preparation of the compound 101 gives a 70% yield of the compound 107 which is obtained in the form of colourless crystals; melting point: 107-110° C. (hexane).

Sources & evidence

ORD record
ord-6d69f4a5b4b14c29913e088faf6df93f
Source dataset
uspto-grants-2008_04
Patent number
US07358365B2

Reaction notes

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