反应详情

Methyl 3-amino-5-(3-chlorophenyl)-2-thiophenecarboxylate (1.0 g), 2M sodium hydroxide (2 mL) and methanol (10 mL) were heated at 70° C. for 2 days. The methanol was evaporated off and the residue was acidified with 2M hydrochloric acid. Extraction into ethyl acetate followed by drying (MgSO4) and evaporation of the solvent gave the sub-title acid (0.8 g).

1. customThe methanol was evaporated off
2. extractionExtraction into ethyl acetate
3. customby drying
4. custom(MgSO4) and evaporation of the solvent