Sodium Hydroxide → HCID 18433637, compound

HRID 900416Notes

Reaction equation

HRID 900416 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=2)[S:4][C:3]=1[C:14]([O:16]C)=[O:15].[OH-].[Na+]>CO>[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=2)[S:4][C:3]=1[C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11994772Methyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate

Product 1

HCID 18433637HCID 18433637, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 3-amino-5-(3-chlorophenyl)-2-thiophenecarboxylate (1.0 g), 2M sodium hydroxide (2 mL) and methanol (10 mL) were heated at 70° C. for 2 days. The methanol was evaporated off and the residue was acidified with 2M hydrochloric acid. Extraction into ethyl acetate followed by drying (MgSO4) and evaporation of the solvent gave the sub-title acid (0.8 g).

Workup

  1. customThe methanol was evaporated off
  2. extractionExtraction into ethyl acetate
  3. customby drying
  4. custom(MgSO4) and evaporation of the solvent

Sources & evidence

ORD record
ord-ce36ed4f035149c6bd94f006df03f94a
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Reaction notes

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