HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 18433637, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate | HCID 11994772 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18433637 | HCID 18433637 | 84.4% |
Reaction Steps
Methyl 3-amino-5-(3-chlorophenyl)-2-thiophenecarboxylate (1.0 g), 2M sodium hydroxide (2 mL) and methanol (10 mL) were heated at 70° C. for 2 days. The methanol was evaporated off and the residue was acidified with 2M hydrochloric acid. Extraction into ethyl acetate followed by drying (MgSO4) and evaporation of the solvent gave the sub-title acid (0.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07358376B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-ce36ed4f035149c6bd94f006df03f94a |
| Source note | uspto-grants-2008_04 |