反应详情

To a solution of furan (7.93 g) in tetrahydrofuran (100 ml) cooled to 5° C. was added dropwise n-butyl lithium (80.2 ml, 1.6M in hexanes). The mixture was stirred for 2 h. A solution of propylene oxide (12.2 ml) was added dropwise and the resulting mixture was stirred at 0° C. for 1 h. The reaction mixture was quenched with saturated ammonium chloride and extracted with diethyl ether. The organics were dried (MgSO4) and concentrated. The crude oil was distilled to give 1-(2-furyl)-propan-2-ol (3.85 g, b.p. 68-70° C. at 6.0 mm).

1. stirringthe resulting mixture was stirred at 0° C. for 1 h
2. customThe reaction mixture was quenched with saturated ammonium chloride
3. extractionextracted with diethyl ether
4. dry with materialThe organics were dried (MgSO4)
5. concentrationconcentrated
6. distillationThe crude oil was distilled