関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| 反応物 | 2-Acetylamino-5-bromo-3-cyanothiophene | HCID 13052850 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Acetylamino-3-cyano-5-(4-cyanophenyl)thiophene | HCID 17930984 | 86.2% |
反応手順
2-Acetylamino-5-bromo-3-cyanothiophene (500 mg), 4-cyanophenylboronic acid (360 mg) and potassium carbonate (845 mg) were added to dimethoxyethane (15 ml) and water (2 ml) and the system purged with argon for 15 minutes. Tetrakis(triphenylphosphine)palladium(0) (236 mg) was added and the mixture heated at 80° C. for 3.25 h. The mixture was cooled, concentrated under reduced pressure to remove most of the dimethoxymethane, dichloromethane added and the mixture filtered to give the product as a pale brown solid (470 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07358376B2 |
|---|
| 出典データセット | uspto-grants-2008_04 |
|---|
| ORD ID | ord-a2eb6bb84e6e47f0b713b54c043d71be |
|---|
| 出典メモ | uspto-grants-2008_04 |
|---|
