反应详情

温度

80 °C

2-Acetylamino-5-bromo-3-cyanothiophene (500 mg), 4-cyanophenylboronic acid (360 mg) and potassium carbonate (845 mg) were added to dimethoxyethane (15 ml) and water (2 ml) and the system purged with argon for 15 minutes. Tetrakis(triphenylphosphine)palladium(0) (236 mg) was added and the mixture heated at 80° C. for 3.25 h. The mixture was cooled, concentrated under reduced pressure to remove most of the dimethoxymethane, dichloromethane added and the mixture filtered to give the product as a pale brown solid (470 mg).

1. customthe system purged with argon for 15 minutes
2. additionTetrakis(triphenylphosphine)palladium(0) (236 mg) was added
3. temperatureThe mixture was cooled
4. concentrationconcentrated under reduced pressure
5. customto remove most of the dimethoxymethane, dichloromethane
6. additionadded
7. filtrationthe mixture filtered