HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900451Generated: October 30, 2026
Cyanoacetamide → 2-Aminothiophene-3-carboxamide
https://huagongshe.com/reaction/900451
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dithiane-2,5-diol | HCID 98330 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Aminothiophene-3-carboxamide | HCID 699495 | — |
Reaction Steps
A suspension of 2,5-dihydroxy-1,4-dithiane (25 g) and cyanoacetamide (19.3 g) in ethanol (120 mL) was stirred and heated to 50° C. Triethylamine (9.2 ml) was added over 15 minutes and the mixture was stirred at 50° C. for a further 2 h. After ice cooling the solid was filtered off and dried (21.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07358376B2 |
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| Source dataset | uspto-grants-2008_04 |
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| ORD ID | ord-47b25b241760462fbe3ec4eaafc0ce7e |
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| Source note | uspto-grants-2008_04 |
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