Cyanoacetamide → 2-Aminothiophene-3-carboxamide
Reaction equation
O[CH:2]1[CH2:7]SC(O)C[S:3]1.[C:9]([CH2:11][C:12]([NH2:14])=[O:13])#[N:10].C(N(CC)CC)C>C(O)C>[NH2:10][C:9]1[S:3][CH:2]=[CH:7][C:11]=1[C:12]([NH2:14])=[O:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
A suspension of 2,5-dihydroxy-1,4-dithiane (25 g) and cyanoacetamide (19.3 g) in ethanol (120 mL) was stirred and heated to 50° C. Triethylamine (9.2 ml) was added over 15 minutes and the mixture was stirred at 50° C. for a further 2 h. After ice cooling the solid was filtered off and dried (21.4 g).
Workup
- stirringthe mixture was stirred at 50° C. for a further 2 h
- filtrationAfter ice cooling the solid was filtered off
- customdried (21.4 g)
Sources & evidence
- ORD record
- ord-47b25b241760462fbe3ec4eaafc0ce7e
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07358376B2
Reaction notes
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