1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 22178188, compound

HRID 900496Notes

Reaction equation

HRID 900496 reaction equation
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][CH:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>O1CCCC1>[OH:1][CH2:27][CH2:28][CH:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

Participants

4

Reactant 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 22178187HCID 22178187, compound2×

Product 1

HCID 22178188HCID 22178188, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(R,S)-hydroxy-pentane-nitrile of the title compound of Example 6a, dissolved in 40 ml of tetrahydrofuran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

Workup

  1. customThen, it is evaporated to the dry state in a vacuum
  2. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

Sources & evidence

ORD record
ord-4e4dbb35dc594369a2d1c821d8794464
Source dataset
uspto-grants-2008_04
Patent number
US07358382B2

Reaction notes

Loading…