Morpholine → [2-(2-Morpholin-4-yl-ethoxy)-5-oxo-tetrahydro-furan-3-yl]-carbamic acid allyl ester

HRID 900621Notes

Reaction equation

HRID 900621 reaction equation
[CH2:1]([O:4][C:5](=[O:17])[NH:6][CH:7]1[CH2:11][C:10](=[O:12])[O:9][CH:8]1[O:13][CH2:14][CH2:15]Cl)[CH:2]=[CH2:3].[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>CN(C=O)C>[CH2:1]([O:4][C:5](=[O:17])[NH:6][CH:7]1[CH2:11][C:10](=[O:12])[O:9][CH:8]1[O:13][CH2:14][CH2:15][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 54096587[2-(2-Chloro-ethoxy)-5-oxo-tetrahydro-furan-3-yl]-carbamic acid allyl ester

Product 1

HCID 53919427[2-(2-Morpholin-4-yl-ethoxy)-5-oxo-tetrahydro-furan-3-yl]-carbamic acid allyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Is prepared from [2-(2-chloro-ethoxy)-5-oxo-tetrahydro-furan-3-yl]-carbamic acid allyl ester by reaction with morpholine (2 eq) and KI (1 eq) in DMF.

Sources & evidence

ORD record
ord-9d4c8225a94a4427bc41fb1529ba6805
Source dataset
uspto-grants-2008_04
Patent number
US07358273B2

Reaction notes

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