HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 11beta-Fluoro-3-methoxyoestra-3,5-dien-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | 11beta-Fluorooestr-4-ene-3,17-dione | HCID 10979145 | — |
| Solvent | 2,2-Dimethoxypropane | HCID 6495 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 11beta-Fluoro-3-methoxyoestra-3,5-dien-17-one | HCID 11738260 | — |
Reaction Steps
7.8 g of 11β-fluoro-estr-4-ene-3,17-dione (A′) was stirred in 40 ml of 2,2-dimethoxypropane with 780 mg of pyridinium-toluene-4-sulfonate for 5 hours at 80° C. Then, 1.5 ml of triethylamine was added. Then, it was diluted with ethyl acetate and washed with saturated sodium chloride solution. After crystallization from methanol, 5.3 g of 11β-fluoro-3-methoxy-estra-3,5-dien-17-one (A″) with a melting point of 173° C. was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361645B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-c73adb54522f424bb8c643c351617319 |
| Source note | uspto-grants-2008_04 |