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HRID900674

反应详情

EQUATION

反应方程式

HRID 900674 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1
HCID466102

未命名化合物

结构：C[C@]12C[C@H](F)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CCC2=O
HCID10979145

未命名化合物

PRODUCTS

生成物

1
结构：COC1=CC2=CC[C@@H]3[C@H]([C@@H](F)C[C@]4(C)C(=O)CC[C@@H]34)[C@H]2CC1
HCID11738260

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：COC(C)(C)OC
溶剂HCID6495

2,2-Dimethoxypropane

C5H12O2

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

7.8 g of 11β-fluoro-estr-4-ene-3,17-dione (A′) was stirred in 40 ml of 2,2-dimethoxypropane with 780 mg of pyridinium-toluene-4-sulfonate for 5 hours at 80° C. Then, 1.5 ml of triethylamine was added. Then, it was diluted with ethyl acetate and washed with saturated sodium chloride solution. After crystallization from methanol, 5.3 g of 11β-fluoro-3-methoxy-estra-3,5-dien-17-one (A″) with a melting point of 173° C. was obtained.

WORKUP

后处理

  1. washwashed with saturated sodium chloride solution
  2. customAfter crystallization from methanol, 5.3 g of 11β-fluoro-3-methoxy-estra-3,5-dien-17-one (A″) with a melting point of 173° C.
  3. customwas obtained