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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 900687Generated: November 4, 2026

Ethyl 4-piperidinecarboxylate → HCID 23117195, compound

https://huagongshe.com/reaction/900687

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-piperidinecarboxylateHCID 70770—
Reactant2,6-Dichloro-5-fluoronicotinic acidHCID 2733659—
SolventDimethylformamideHCID 6228—
ProductHCID 23117195HCID 23117195—

Reaction Conditions

Temperature80 °C

Reaction Steps

Ethyl isonipecotate was added to a DMF solution of 2,6-dichloro-5-fluoronicotinic acid, and the mixture was stirred at 80° C. to obtain 2-chloro-6-[4-(ethoxycarbonyl)piperidin-1-yl]-5-fluoronicotinic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07361658B2
Source datasetuspto-grants-2008_04
ORD IDord-08fce13138a041259e300f3e9c75d447
Source noteuspto-grants-2008_04