反应详情

温度

60 °C

0.4 ml of a 1M sodium hydroxide aqueous solution was added to a 1.5 ml EtOH suspension of 76 mg of ethyl 1-{3-chloro-5-[(4-(4-chlorothiophen-2-yl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}thiazol-2-yl)carbamoyl]-2-pyridyl}piperidine-4-carboxylate, and the mixture was stirred at 60° C. for 2 hours. 0.6 ml of 1M hydrochloric acid and 0.5 ml of water were added at room temperature, and the resulting precipitate was collected by filtration, washed with 50% ethanol water, and dried under reduced pressure to obtain 73 mg of 1-{3-chloro-5-[(4-(4-chlorothiophen-2-yl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}thiazol-2-yl)carbamoyl]-2-pyridyl}piperidine-4-carboxylic acid hydrochloride.

1. filtrationthe resulting precipitate was collected by filtration
2. washwashed with 50% ethanol water
3. customdried under reduced pressure