HCID 22226540, compound → HCID 22226489, compound

HRID 900712Notes

Reaction equation

HRID 900712 reaction equation
[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7]([CH2:18][C:19]([OH:21])=[O:20])=[CH:6][N:5]=1)([CH3:3])[CH3:2].[CH3:22]OC1C=C2C(C(C(C)C(O)=O)=CN=C2N2CCOCC2)=CC=1>>[C:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7]([CH2:18][C:19]([OH:21])=[O:20])=[CH:6][N:5]=1)([CH3:22])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 22226540HCID 22226540, compoundHCID 22226554HCID 22226554, compound

Product 1

HCID 22226489HCID 22226489, compound

Procedure

(1-Isopropyl-6,7-dimethoxy-isoquinolin-4-yl)-acetic acid, characterised as the ethyl ester 1H NMR (400 MHz, CDCl3) δ 1.25 (t J 7 3H), 1.45 (d J 7 3H), 3.82 (heptet J 7 1H), 3.90 (s 2H), 3.08 (s 2H), 4.15 (q J 7 2H), 7.28 (s 1H), 7.48 (s 1H), 8.30 (s 1H). Intermediate 41: 2-(7Methoxy-1-morpholin-4-yl-isoquinolin4-yl)-propionic acid mp 225-227° C., is prepared according to the procedure for Intermediate 27.

Sources & evidence

ORD record
ord-eb8ad7e088b84bf286a425272519619f
Source dataset
uspto-grants-2008_04
Patent number
US07361661B2

Reaction notes

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