反应详情

To a dichloromethane solution (2 mL) of N-(3-chloro-phenyl)-2-(5-pyridin-3-yl-2H-[1,2,4]triazol-3-ylsulfanyl)-acetamide (0.080 g, 0.25 mmol), m-chloroperbenzoic acid (0.25 mmol) was and the mixture was stirred for 2 h. The reaction mixture was quenched with sodium bicarbonate solution and the product extracted in ethyl acetate. The ethyl acetate layer was dried, filtered and evaporated to afford crude residue. This residue was purified by reverse phase HPLC to afford pure title compound (40 mg, 45%). MS (ES) 361.5

1. customThe reaction mixture was quenched with sodium bicarbonate solution
2. extractionthe product extracted in ethyl acetate
3. dry with materialThe ethyl acetate layer was dried
4. filtrationfiltered
5. customevaporated
6. customto afford crude residue
7. customThis residue was purified by reverse phase HPLC