反应详情

温度

140 °C

The sulfone from Step B (101 mg, 0.567 mmol) was dissolved in NMP (2 ml). To this solution 2-amino-N-(3-chlorophenyl)-acetamide (116 mg, 5 mmol) was added, and the mixture was heated at 140° C. for 12 h. The mixture was loaded directly onto an HPLC reverse phase column and purified by water to acetonitrile gradient in the presence of 0.1% trifluoroacetic acid. The aqueous phase was evaporated by lyophilization to yield the title compound as a fluffy white solid (166 mg, 85% yield). ES (MS): 345.12 (M+H)+

1. custompurified by water to acetonitrile gradient in the presence of 0.1% trifluoroacetic acid
2. customThe aqueous phase was evaporated by lyophilization