HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 17974697, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propane, 1-iodo-2,2-dimethyl- | HCID 84953 | — |
| Reactant | 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione | HCID 96141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 17974697 | HCID 17974697 | — |
Reaction Steps
6-Chloro-3-methyl uracil (10.0 g) and potassium carbonate (10.34 g) in DMF (70 ml) under nitrogen were treated with neopentyl iodide (9.9 ml) and stirred for 48 h. Neopentyl iodide (7.4 ml) was added and the reaction was stirred under reflux for a further 37 h. The reaction was poured into water (700 ml) and extracted with ethyl acetate. The combined organics were dried and concentrated in vacuo to afford the subtitle compound an orange oil, 8.1 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361660B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-df335f846d8342969530530b4f9165a7 |
| Source note | uspto-grants-2008_04 |