Water → HCID 17974697, compound

HRID 900742Notes

Reaction equation

HRID 900742 reaction equation
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:17](I)[C:18]([CH3:21])([CH3:20])[CH3:19].O>CN(C=O)C>[Cl:1][C:2]1[N:7]([CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 84953Propane, 1-iodo-2,2-dimethyl-2×HCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 17974697HCID 17974697, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6-Chloro-3-methyl uracil (10.0 g) and potassium carbonate (10.34 g) in DMF (70 ml) under nitrogen were treated with neopentyl iodide (9.9 ml) and stirred for 48 h. Neopentyl iodide (7.4 ml) was added and the reaction was stirred under reflux for a further 37 h. The reaction was poured into water (700 ml) and extracted with ethyl acetate. The combined organics were dried and concentrated in vacuo to afford the subtitle compound an orange oil, 8.1 g.

Workup

  1. stirringthe reaction was stirred
  2. temperatureunder reflux for a further 37 h
  3. extractionextracted with ethyl acetate
  4. customThe combined organics were dried
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-df335f846d8342969530530b4f9165a7
Source dataset
uspto-grants-2008_04
Patent number
US07361660B2

Reaction notes

Loading…