1-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one → Methyl 6-[2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-ylmethyl]-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-5-carboxylate

HRID 900745Notes

Reaction equation

HRID 900745 reaction equation
Br[CH2:2][C:3]1[S:18][C:6]2[N:7]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=2[C:4]=1[C:19]([O:21][CH3:22])=[O:20].[CH3:23][N:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[NH:26][C:25]1=[O:33]>>[CH3:23][N:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[N:26]([CH2:2][C:3]2[S:18][C:6]3[N:7]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:8](=[O:13])[N:9]([CH3:12])[C:10](=[O:11])[C:5]=3[C:4]=2[C:19]([O:21][CH3:22])=[O:20])[C:25]1=[O:33]

Participants

3

Reactant 2

HCID 5905401-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-oneHCID 16102871Methyl 6-bromomethyl-1-isobutyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate

Product 1

HCID 69197857Methyl 6-[2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-ylmethyl]-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-5-carboxylate

Procedure

The subtitle compound was prepared by the method of example 1 step c) using the product of example 1 step b) and N-methylbenzimidazolone.

Sources & evidence

ORD record
ord-bf275b09665e415c97a09eebe07ae8d6
Source dataset
uspto-grants-2008_04
Patent number
US07361660B2

Reaction notes

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