Hydrochloric Acid → (4,5-Dichloro-1H-imidazol-2-yl)methanol

HRID 900750Notes

Reaction equation

HRID 900750 reaction equation
[OH-:1].[K+].[Cl:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[Cl:9].[CH2:10]=O.Cl>O>[Cl:3][C:4]1[N:5]=[C:6]([CH2:10][OH:1])[NH:7][C:8]=1[Cl:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14797Potassium HydroxideHCID 1400184,5-Dichloroimidazole

Product 1

HCID 17974733(4,5-Dichloro-1H-imidazol-2-yl)methanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium hydroxide (0.12 g, 2.14 mmol) in water (4 ml) was added to 4,5-dichloroimidazole, and the suspension was stirred for 35 min. Paraformaldehyde (0.11 g, 3.66 mmol) was added portionwise and the reaction mixture was stirred over night, then acidified with dilute HCl to pH 1 and then concentrated in vacuo to give a white solid, 0.6 g (98%).

Workup

  1. stirringthe reaction mixture was stirred over night
  2. concentrationconcentrated in vacuo
  3. customto give a white solid, 0.6 g (98%)

Sources & evidence

ORD record
ord-bf606cbed2f74542bad9de68bf2a5821
Source dataset
uspto-grants-2008_04
Patent number
US07361660B2

Reaction notes

Loading…