反应详情

Neat DIPEA (1.54 ml, 8.86 mmol) was added dropwise to a solution of phenyl(4-piperidinyl)methanone hydrochloride (1 g, 4.43 mmol) in CH2Cl2 (20 ml) at 0° C. Then, neat MsCl (377 μL, 4.87 mmol) was slowly added and the cooling bath was removed. After 30 minutes, the reaction was quenched with water and diluted with CH2Cl2. After separation, the organic phase was washed with brine, dried over MgSO4 and evaporated to dryness. The final ketone 1 was obtained as a white solid (1.16 g, 98%).

1. customthe cooling bath was removed
2. customthe reaction was quenched with water
3. additiondiluted with CH2Cl2
4. customAfter separation
5. washthe organic phase was washed with brine
6. dry with materialdried over MgSO4
7. customevaporated to dryness