反应详情

To an etheral solution of cyclobutyl magnesium bromide (prepared from bromocyclobutane (970 mg, 7.18 mmol) and magnesium (175 mg, 7.18 mmol) in ether (20 ml)) was dropwise added a solution of 2-cyanopyridine (748 mg, 7.18 mmol) in ether (10 ml) at room temperature. After 2 hours, the reaction was quenched by addition of an aqueous saturated solution of NH4Cl. The mixture was extracted with ether. The organic phase was dried over MgSO4 and concentrated under vacuum. The residue was purified by chromatography on silica gel (hexane/AcOEt 95/5) to give the cyclobutyl(2-pyridinyl)methanone 7 as colorless oil (960 mg, 83%).

1. customthe reaction was quenched by addition of an aqueous saturated solution of NH4Cl
2. extractionThe mixture was extracted with ether
3. dry with materialThe organic phase was dried over MgSO4
4. concentrationconcentrated under vacuum
5. customThe residue was purified by chromatography on silica gel (hexane/AcOEt 95/5)