Chloride → HCID 16110249, compound

HRID 900802Notes

Reaction equation

HRID 900802 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:18])[C:15](O)=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-:19]>>[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:18])[C:15]([Cl:19])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 312ChlorideHCID 16110264(4-Benzylpiperidin-1-yl)oxoacetic acid

Product 1

HCID 16110249HCID 16110249, compoundYield 99.5%

Procedure

A mixture of 26.2 g (106 mmol) of (4-benzylpiperidin-1-yl)oxoacetic acid and 50 ml of thinyl chloride is refluxed for 2 h, then cooled and concentrated to yield 28.0 g (99.5%) of the title compound as an oil.

Workup

  1. temperatureis refluxed for 2 h
  2. temperaturecooled
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-37c9e7fd63bf4f5882a20d1ec629e1af
Source dataset
uspto-grants-2008_04
Patent number
US07361670B2

Reaction notes

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