5-Chloro-4-nitrothiophene-2-sulfonamide → HCID 67218382、化合物

HRID 900862ノート

反応式

HRID 900862 の反応式
[Cl:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[CH:4][C:3]=1[N+:11]([O-])=O>CO>[NH2:11][C:3]1[CH:4]=[C:5]([S:7]([NH2:10])(=[O:8])=[O:9])[S:6][C:2]=1[Cl:1]

参加物

3

反応物 1

HCID 27357825-Chloro-4-nitrothiophene-2-sulfonamide

生成物 1

HCID 67218382HCID 67218382、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Hydrogenation of a stirred solution of 5-chloro-4-nitro-thiophene-2-sulfonamide [CAS-No. 61714-46-3; commercially available] (1.13 g, 4.66 mmol) in methanol (140 ml) on Raney-Nickel (1.13 g) for 3 h at room temperature yielded after removal of the catalyst by filtration, evaporation and column chromatography on silica gel (ethyl acetate/hexane) the title compound as a light brown solid. MS (ISP) 211.0 [(M−H)−], mp 138° C.

後処理

  1. customafter removal of the catalyst
  2. filtrationby filtration, evaporation and column chromatography on silica gel (ethyl acetate/hexane) the title compound as a light brown solid

出典と根拠

ORDレコード
ord-2f97eb9ac61a45f791446533073f4ad6
出典データセット
uspto-grants-2008_04
特許番号
US07361659B2

反応ノート

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