5-Chloro-4-nitrothiophene-2-sulfonamide → HCID 67218382, compound

Participants

Reaction Steps

Hydrogenation of a stirred solution of 5-chloro-4-nitro-thiophene-2-sulfonamide [CAS-No. 61714-46-3; commercially available] (1.13 g, 4.66 mmol) in methanol (140 ml) on Raney-Nickel (1.13 g) for 3 h at room temperature yielded after removal of the catalyst by filtration, evaporation and column chromatography on silica gel (ethyl acetate/hexane) the title compound as a light brown solid. MS (ISP) 211.0 [(M−H)−], mp 138° C.

Provenance & Evidence