4-Amino-5-chloro-thiophene-2-sulfonic acid bis-(2-hydroxy-ethyl)-amide → 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {5-[bis-(2-hydroxy-ethyl)-sulfamoyl]-2-chloro-thiophen-3-yl}-amide

HRID 900917Notes

Reaction equation

HRID 900917 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[OH:27][CH2:28][CH2:29][N:30]([CH2:41][CH2:42][OH:43])[S:31]([C:34]1[S:35][C:36]([Cl:40])=[C:37]([NH2:39])[CH:38]=1)(=[O:33])=[O:32]>>[OH:27][CH2:28][CH2:29][N:30]([CH2:41][CH2:42][OH:43])[S:31]([C:34]1[S:35][C:36]([Cl:40])=[C:37]([NH:39][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:38]=1)(=[O:32])=[O:33]

Participants

3

Reactant 2

HCID 672184874-Amino-5-chloro-thiophene-2-sulfonic acid bis-(2-hydroxy-ethyl)-amideHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 119974657-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {5-[bis-(2-hydroxy-ethyl)-sulfamoyl]-2-chloro-thiophen-3-yl}-amide

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 4-amino-5-chloro-thiophene-2-sulfonic acid bis-(2-hydroxy-ethyl)-amide (example B.5) according to general procedure II.

Sources & evidence

ORD record
ord-4c8fb0007e8c4a9d999985e5a87cc992
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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