HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-ylamine → 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [4-methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-ylamine | HCID 63946172 | — |
| Reactant | 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 86607112 | — |
| Product | 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [4-methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-yl]-amide | HCID 86607124 | — |
Reaction Steps
The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 4-methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-ylamine (example B.19) according to general procedure II. Yellow solid. MS (ISP) 634.1 [(M+H)+]; mp 273° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361659B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-872b3bd14fdc49e2a1a11ee8b17becb8 |
| Source note | uspto-grants-2008_04 |