HCID 63946621, compound → 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [(RS)-5-(3-hydroxy-pyrrolidine-1-sulfonyl)-4-methyl-thiazol-2-yl]-amide

HRID 900957Notes

Reaction equation

HRID 900957 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:27][C:28]1[S:29][C:30]([S:34]([N:37]2[CH2:41][CH2:40][CH:39]([OH:42])[CH2:38]2)(=[O:36])=[O:35])=[C:31]([CH3:33])[N:32]=1>>[OH:42][CH:39]1[CH2:40][CH2:41][N:37]([S:34]([C:30]2[S:29][C:28]([NH:27][C:12]([C:11]3[CH:10]=[N:9][N:8]4[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]5[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=5)=[N:6][C:7]=34)=[O:13])=[N:32][C:31]=2[CH3:33])(=[O:36])=[O:35])[CH2:38]1

Participants

3

Reactant 2

HCID 63946621HCID 63946621, compoundHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 731732647-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [(RS)-5-(3-hydroxy-pyrrolidine-1-sulfonyl)-4-methyl-thiazol-2-yl]-amide

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and (RS)-1-(2-amino-4-methyl-thiazole-5-sulfonyl)-pyrrolidin-3-ol (example B.23) according to general procedure II. Light yellow solid. MS (ISP) 621.0 [(M+H)+]; mp 300° C.

Sources & evidence

ORD record
ord-2afe7bc53f764ace9b22b5dc33d0c640
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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