tert-Butyl piperazine-1-carboxylate → HCID 59698837, compound

HRID 901033Notes

Reaction equation

HRID 901033 reaction equation
C(O[C:4](=[O:21])[CH2:5][C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[S:9][CH:10]=1)C.[C:22]([O:26][C:27]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)=[O:28])([CH3:25])([CH3:24])[CH3:23]>C1COCC1>[C:22]([O:26][C:27]([N:29]1[CH2:34][CH2:33][N:32]([C:4](=[O:21])[CH2:5][C:6]2[N:7]=[C:8]([NH:11][C:12](=[O:20])[C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[S:9][CH:10]=2)[CH2:31][CH2:30]1)=[O:28])([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 674896HCID 674896, compound

Product 1

HCID 59698837HCID 59698837, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

54.1 Using general method A, with THF instead of DMF as solvent, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid ethyl ester (example 1.1) was coupled with tert-butyl-1-piperazine carboxylate to give 4-{2-[2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetyl}-piperazine-1-carboxylic acid tert-butyl ester. White solid. MS 465.1 ([M+H]+)

Sources & evidence

ORD record
ord-ca399eac12654f6d99be923d489cab9d
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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