1-(1-Methyl-4-piperidinyl)piperazine → HCID 59698885, compound

HRID 901044Notes

Reaction equation

HRID 901044 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH2:14][C:15]([OH:17])=O)[N:10]=2)=[O:7])=[CH:4][CH:3]=1.[CH3:20][N:21]1[CH2:26][CH2:25][CH:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH2:14][C:15]([N:30]3[CH2:29][CH2:28][N:27]([CH:24]4[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]4)[CH2:32][CH2:31]3)=[O:17])[N:10]=2)=[O:7])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 59698879HCID 59698879, compound

Product 1

HCID 59698885HCID 59698885, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using general method A, using THF instead of DMF as solvent, [3-(4-chloro-benzoylamino)-pyrazol-1-yl]-acetic acid (example 59.2) was reacted with 1-(N-methyl-4-piperidyl)-piperazine to give 4-chloro-N-(1-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-1H-pyrazol-3-yl)-benzamide. Off-white solid. MS 445.4 ([M+H]+)

Sources & evidence

ORD record
ord-dcc156c5d55545fdac22064ab5b391a1
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

Loading…